抜きで details

ぬきで

without X; leaving X out

今日きょうは冗談じょうだん抜ぬきで話はなそう。

kyou wa joudan nuki de hanasou.

Let's talk seriously today, no jokes. casual

朝食ちょうしょく抜ぬきで出でかけたので、もうお腹なかがすいた。

choushoku nuki de dekaketa node, mou onaka ga suita.

I left without breakfast, so I'm already hungry. neutral

Examples

without N; leaving N out — an element normally expected is omitted from the event or thing described

今日きょうは冗談じょうだん抜ぬきで話はなそう。

kyou wa joudan nuki de hanasou.

Let's talk seriously today, no jokes. casual

朝食ちょうしょく抜ぬきで出でかけたので、もうお腹なかがすいた。

choushoku nuki de dekaketa node, mou onaka ga suita.

I left without breakfast, so I'm already hungry. neutral

前置まえおき抜ぬきで、本題ほんだいに入はいらせていただきます。

maeoki nuki de, hondai ni hairasete itadakimasu.

Without further preamble, allow me to get straight to the main topic. formal

抜きにして — にして makes the omission an explicit announcement rather than a background adverbial — 冗談じょうだんは抜ぬきにして、真剣しんけんな話はなしをしよう "joking aside, let's get serious" — the shape that opens a topic change.

を除いて
を除いて subtracts N from a larger set and describes what remains true across that whole set (日曜日にちようびを除のぞいて毎日まいにち); 抜きで pulls one expected ELEMENT out of a single event or thing and describes what happens without that ingredient (朝食ちょうしょく抜きで出でかけた) — を除いて counts members of a group, 抜きで strips a component from something singular.

抜く
Same 抜 character, unrelated jobs — the verb 抜く's ますstem intensifies persistence THROUGH an ongoing action (走はしり抜く, push all the way through); 抜きで's 抜き is a noun meaning "omission," pulling an expected element OUT of an event before it starts (朝食抜きで) — one adds effort, the other subtracts an ingredient.